MigraSpray contains only natural, standardized ingredients, and is made by strictly adhering to Good Manufacturing Practices (GMP). There have been no reported side effects and no incidents of drug interaction with any over-the-counter or prescription medications. The active ingredients include polyporus, goldenseal, dandelion and fever few, its primary component. For centuries, fever few has been used to treat a variety of ailments including headaches, rheumatic aches, abdominal pain and menstrual cramps. Studies have shown that fever few acts as a natural anti-inflammatory, suppressing inflammation occurring in the cerebral blood vessels — believed to contribute to migraine headache symptoms.